Search on: PYRROLIZIDINE ALKALOIDS 
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Descriptor English:   Pyrrolizidine Alkaloids 
Descriptor Spanish:   Alcaloides de Pirrolicidina 
Descriptor Portuguese:   Alcaloides de Pirrolizidina 
Synonyms English:   Alkaloids, Pyrrolizidine
Alkaloids, Senecio
Senecio Alkaloids  
Tree Number:   D03.132.716
D03.633.100.772
Definition English:   A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS. 
History Note English:   73(71) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   12200 
Unique Identifier:   D011763 

Occurrence in VHL:
 

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